optimizing formulation variables of kcl loaded waxy microspheres

نویسندگان

hossein shaki

biomedical engineering group, chemical engineering faculty,tarbiat modares university, tehran, iran ebrahim vasheghani-farahani

biomedical engineering group, chemical engineering faculty,tarbiat modares university, tehran, iran seyed abas shojaosadati

biomedical engineering group, chemical engineering faculty,tarbiat modares university, tehran, iran fariba ganji

biomedical engineering group, chemical engineering faculty,tarbiat modares university, tehran, iran

چکیده

potassium chloride (kcl) is a highly water soluble substance which is usually used to prevent hypokalemia. oil in water disperse phase encapsulation method was used to prepare kcl loaded microcapsules using beeswax and carnauba wax as a hydrophobic matrix. the morphology and characteristics of kcl loaded microspheres were studied using scanning electron microscopy (sem), photon correlation spectroscopy (pcs) and differential scanning calorimetery (dsc). the particle size distribution of resulting microspheres was narrow and dsc diagrams showed no interaction between waxes and drug. the effective variables were determined using plackett-burman design followed by response surface methodology for optimization of these variables. based on this analysis, the most effective parameters on drug loading were found to be beeswax/carnauba wax ratio, drug/wax ratio and rate of emulsification. using the response surface method, the optimum values of effective parameters were found to be beeswax/carnauba wax ratio =6.245, drug/wax ratio = 0.668 and rate of emulsification = 679.8 rpm.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Optimizing Formulation Variables of KCl Loaded Waxy Microspheres

Potassium chloride (KCl) is a highly water soluble substance which is usually used to prevent hypokalemia. Oil in water disperse phase encapsulation method was used to prepare KCl loaded microcapsules using beeswax and carnauba wax as a hydrophobic matrix. The morphology and characteristics of KCl loaded microspheres were studied using scanning electron microscopy (SEM), photon correlation spec...

متن کامل

Effect of Formulation Variables on Rifampicin Loaded Alginate Beads

The present work investigated the preparation of biodegradable beads with alginate polymer by ionotropic gelation method to improve the control release properties of the antibiotic rifampicin. Ionotropic gelation method was applied to prepare beads using calcium chloride (CaCl2) as cationic component and alginate as an anionic component. In this method, adding 0.5% w/v polyvinyl alcohol (PVA) t...

متن کامل

Effect of Formulation Variables on Rifampicin Loaded Alginate Beads

The present work investigated the preparation of biodegradable beads with alginate polymer by ionotropic gelation method to improve the control release properties of the antibiotic rifampicin. Ionotropic gelation method was applied to prepare beads using calcium chloride (CaCl2) as cationic component and alginate as an anionic component. In this method, adding 0.5% w/v polyvinyl alcohol (PVA) t...

متن کامل

Formulation, and Evaluation of Pentoxifylline-Loaded Poly(ε-caprolactone) Microspheres

Pentoxifylline-loaded poly(epsilon-caprolactone) microspheres were prepared by solvent evaporation technique with different drug to carrier ratio F1 (1:3), F2 (1:4), F3 (1:5) and F4 (1:6). The microspheres were characterized for particle size, scanning electron microscopy, FT-IR study, percentage yield, drug entrapment, stability studies and for in vitro release kinetics. The shape of microsphe...

متن کامل

Formulation and evaluation of Bacillus coagulans-loaded hypromellose mucoadhesive microspheres

Development of a novel delivery system has been attempted to deliver viable probiotic cells into the gut for a prolonged period of time while maintaining high numbers of viable cells within the formulation throughout the shelf-life of the product and during the gastrointestinal transit. Core mucoadhesive microspheres of Bacillus coagulans were developed employing several grades of hypromellose,...

متن کامل

Formulation and Evaluation of Octreotide Acetate Loaded Plga Microspheres

Objective: The objective of the present work was to formulate and evaluate controlled release Octreotide acetate microspheres for subcutaneous administration for treating symptoms associated with metastatic carcinoid and vasoactive intestinal peptide tumors (VIPsecreting tumors) and acromegaly effectively and also to improve patient compliance with fewer side effects. Octreotide is a long actin...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmaceutical sciences

جلد ۱۰، شماره ۱، صفحات ۳۷-۵۴

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023